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Non‐alcoholic fatty liver disease in a sample of individuals with bipolar disorders: results from the FACE‐BD Cohort

Acta Psychiatrica Scandinavica Oct 07, 2020

Godin O, Leboyer M, Belzeaux R, et al. - In a large sample of patients with bipolar disorders (BD), researchers sought to estimate the prevalence of nonalcoholic fatty liver disease (NAFLD) and to identify the potential associated risk factors. One-thousand nine-hundred sixty-nine BD people from the FACE‐BD cohort were included between 2009 and 2019. The study omitted people with liver diseases, hepatitis B or C, and current alcohol use disorders. In this sample, the prevalence of NAFLD was estimated at 28.4%; when broken down by gender 40% of men and 21% of women had NAFLD. Older age, male gender, sleep disturbances and current use of atypical antipsychotics or anxiolytics were independently related to NAFLD. This research supports the position that people with BD are particularly susceptible to cardiovascular and metabolic diseases. In individuals with BD, the prevalence of NAFLD was two times greater than the prevalence reported in the general population. Therefore, the standard screening of MetS in people with BD should be accompanied by NAFLD screening for these susceptible individuals.

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