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No major reduction in bone mineral density after long-term treatment of patients with celiac disease

European Journal of Internal Medicine Sep 06, 2019

Hære P, et al. - Because patients with celiac disease (CD) have demonstrated lower BMD than healthy control participants at the time of diagnosis, researchers ascertained if adult patients with CD could regain normal BMD following gluten-free diet (GFD) treatment. Dual-energy X-ray absorptiometry (DXA) was used to determine BMD at the femoral neck and spine L2-4 in patients with CD (adult diagnosis) who had been treated with GFD for ≥ 2 years. Using the Celiac Disease Adherence Test scoring tool, adherence to GFD was measured. A total of 143 patients with CD (mean age: 55.8 years; mean treatment duration: 9.3 years) had DXA assessment. According to findings, the prevalence of low bone mass was 18.2% at the femoral neck and 23.1% at spine L2-4. The investigators observed a slight increase in the prevalence of low bone density at the lumbar spine, restricted to postmenopausal women. When adjusted for age, sex, ethnicity, and weight, the majority of the patients with CD had a normal bone density after 2 years of treatment with GFD.

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