Musella M, et al. - Researchers designed a prospective cohort case-control study to assess the expression of ghrelin-producing cells (GPC) in two groups of patients to understand the role of ghrelin in the mechanism of action of laparoscopic sleeve gastrectomy (LSG). Using immunohistochemistry, they compared specimens of resected stomach from 26 obese patients who underwent LSG (group A) to control stomach samples from 26 non-obese patients (group B) resected for other pathologies or during autopsy. The stomach of obese and non-obese controls displayed similarity in terms of GPC expression. The expression was mostly influenced by the inflammatory status of the gastric mucosa. The weight loss in patients who underwent LSG was not influenced by a variation in the preoperative number of GPC.