Lecuyer L, et al. - Herein, the possible contribution of plasma untargeted metabolomic profiles, established from a simple blood draw from healthy women, to predict the risk of developing breast cancer within the following decade as well as to better understand the aetiology of this complex disease was investigated. Essentially, associations were apparent between baseline nuclear magnetic resonance (NMR) plasma metabolomic signatures and long-term breast cancer risk. In addition, findings offer interesting insights to better understand complex mechanisms involved in breast carcinogenesis and evoke plasma metabolic disorders favourable for carcinogenesis initiation. Additionally, the results may contribute to develop screening strategies for the detection of at-risk women for breast cancer well before symptoms appear.