Solano JA, del Valle C, Rodríguez‐Miguel A, et al. - Researchers conducted a single‐blind stratified randomized clinical trial with masked assessment by a third‐party in order to compare the effect of inhaled nitrous oxide (INO) on pain control during in‐office hysteroscopy with 1%‐lidocaine paracervical infiltration and no‐analgesic. They stratified 314 women into three groups according to the purpose of the hysteroscopy (biopsy, polypectomy or tubal sterilisation) and then assigned them to different treatment groups. Findings support equivalent effectiveness of INO and lidocaine‐1% in pain control for in‐office hysteroscopy; INO was better tolerated. The poorer results were achieved in the no‐analgesic group, thus it was the least recommended clinical option.