Nelson KA, Thaker AA, Callen AL, et al. - This study was undertaken to explore the utility of contrast MR-sequences in assessment of seizure in patients without suspicion for neoplasia or infection. Researchers examined imaging and clinical data for 103 consecutive patients admitted for phase-1 seizure monitoring with the following criteria: MRI-brain conducted with/without intravenous contrast, no clinical suspicion for central nervous system (CNS) infection and no history of CNS neoplasia, or suspected metastatic disease. The results showed that in initial screening of adult new-onset seizure patients without clinically suspected neoplasia or infection, contrast MR-imaging has limited diagnostic utility. In this patient population, more judicious use of contrast MR-imaging may decrease unnecessary exposure to gadolinium and lower associated healthcare costs.