Li C, et al. - Researchers investigated whether neutrophils density and human papillomavirus (HPV) status can be used to define a high-risk category of patients in oral squamous cell carcinoma (OSCC) and studied the possible connection between them. In 81 patients with OSCC, they conducted immunohistochemistry to probe neutrophils infiltration and HPV (P16) expression. According to results, higher numbers of CD15+ neutrophils infiltration was associated with stage Ⅲ，Ⅳ, poor grade, lymph node metastasis, and the higher preoperative neutrophil-lymphocyte ratio (NLR). In addition, HPV-negative status was linked to stage Ⅲ，Ⅳ, poor grade, lymph node metastasis, radiotherapy, and higher NLR. The authors concluded that HPV status and neutrophils infiltration seem to be prognostic parameters for OSCC. To some extent, overexpression of HPV18 E7 on OSCC cells may be involved in depressing infiltration of neutrophils by downregulating IL-8 expression.