Ramanathan K, et al. - Researchers, herein, used public microarray datasets and new clinical samples to recognize and authenticate neutrophil gene expression signatures in JIA. Findings revealed elevated low-density granulocytes (LDGs) in JIA and their contribution to the transcriptomic profile of JIA peripheral blood mononuclear cells (PBMCs). Via expressing higher levels of MMP8 and FCGR1B and releasing proteases and reactive oxygen metabolites resulting in systemic inflammation and damage to joints, JIA neutrophils were suggested to be possibly involved in disease pathology.