Terracciano A, Aschwanden D, Stephan Y, et al. - In this study, the relationship between neuroticism and risk of Parkinson disease (PD) was explored in a large cohort and a meta‐analysis of prospective cohort studies. Between 2006 and 2010, individuals from the UK Biobank (N = 490,755) completed a neuroticism scale. Researchers determined incident PD using electronic health records or death records up to 2018. The outcomes from the large UK Biobank and meta‐analysis of prospective studies demonstrate that neuroticism is consistently correlated with a higher risk of incident PD. Even after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up, this association remained significant, and the associations were comparable for men and women.