Bougea A, et al. - In this prospective cross-sectional study, researchers compared the neuropsychiatric and cerebrospinal fluid (CSF) α-Synuclein (α-Syn) profiles in conditions like Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD), and examined the possible relationship between CSF α-Syn levels and neuropsychiatric symptoms. Participants in the study were 16 PDD, 28 DLB and 19 AD patients between January 2013 and January 2015. No association was found between Neuropsychiatric Inventory (NPI) scores and α-Syn levels. Still, increased NPI scores and α-Syn levels are linked to greater likelihood for being in DLB than in PDD or AD groups. The findings from the present study suggested that NPI scores and CSF α-Syn levels were valuable as independent variables to differentiate DLB from PDD and AD.