Wang CH, Chang WT, Su KI, et al. - Via conducting a systematic review and meta-analysis, researchers sought to inscribe and compare the prognostic accuracy of the blood biomarkers of brain injury, including NSE and S-100B, for neurological outcomes in adult postcardiac arrest patients. Searching PubMed and Embase databases from their inception to March 2019, they included 42 studies involving 4,806 patients in the meta-analysis. Outcomes revealed comparable prognostic performance of NSE and S-100B. The NSE was correlated with a pooled sensitivity of 0.56 and pooled specificity of 0.99. The S-100B was linked with a pooled sensitivity of 0.63 and pooled specificity of 0.97. They recognized a low heterogeneity for NSE (I², 22.4%) and S-100B (I², 16.1%) and non significant publication bias. For postcardiac arrest patients, a multimodal neuroprognostication algorithm integrating both biomarkers seems valuable and they recommend establishing institution-specific cut-off points for both biomarkers.