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Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues

Cancer Management and Research Jul 21, 2018

Seifi-Alan M, et al. - Researchers tested the premise that expression of neuropilin-1 (NRP1) in breast cancer tissues is associated with clinicopathological data of patients and expression of the tumor suppressor miR-206. They used real-time polymerase chain reaction to assess NRP1 expression in 48 invasive ductal carcinomas of the breast and their corresponding adjacent noncancerous tissues (ANCTs). They assessed the correlation between expression levels of miR-206 and NRP1 by using data on miR-206 gene expression from the same cohort of patients. Based on the findings, they concluded that metastasis potential in breast cancer might be indicated by NRP1 protein levels.

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