Velasco R, et al. – This prospective clinical–pathological study aimed to examine the changes in serum nerve growth factor (NGF) and intraepidermal nerve fiber density (IENFD) in skin biopsies of cancer patients receiving neurotoxic chemotherapy in a single–center prospective observational study. In cancer patients receiving taxane or platinum with painful chemotherapy–induced peripheral neuropathy (CIPN), serum NGF increased, implying that it could be a potential biomarker of presence and severity of neuropathic pain in this population. To better define the course of NGF in relation with neurological outcomes, long–term comprehensive studies would be helpful in the further design of therapies for CIPN related neuropathic pain.