Schrage B, et al. - In this study, researchers estimated the predictive ability of neuron-specific-enolase (NSE) in extracorporeal membrane oxygenation therapy (ECMO) patients. In the derivation cohort of 65 post-CPR ECMO patients, they measured NSE after 24, 48, and 72 hours and evaluated neurologic status using the best Cerebral Performance Categories Score (CPC) during the hospital stay. Outcomes suggest a possible utility of NSE in assessing the neurologic outcome. They identified the best discrimination using NSE measurement after 48 hours for poor neurological outcome (AUC of 0.87 in the ROC curve; cut-off value of 70 μg/L). Using serial NSE measurements, the highest specificity was observed.