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Neurologic involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome

JAMA Neurology May 18, 2021

LaRovere KL, Riggs BJ, Poussaint TY, et al. - Researchers conducted the study for analyzing the range and severity of neurologic involvement among children and adolescents associated with COVID-19. The sample consisted of 1,695 patients (909 male [54%]; median [interquartile range] age, 9.1 [2.4-15.3] years). Patients with neurologic involvement were more likely to have underlying neurologic disorders (81 [22%]) than those without (113 [8%]), such as seizure disorders, neuromuscular disorders, and autism or developmental delay. According to this study, many children and adolescents hospitalized for COVID-19 or multisystem inflammatory syndrome in children had neurologic involvement, mostly transient symptoms. A variety of life-threatening and fatal neurologic conditions were associated with COVID-19 on an infrequent basis. The long-term effects on neurodevelopmental outcomes are unknown.

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