Noubiap JJ, et al. – This meta–analysis aims to summarize prevalence data on the neurologic complications of sickle cell disease (SCD) in Africa. In Africa, the burden of neurologic complications of SCD is important and most likely underestimated. Using standard up–to–date screening methods, a better evaluation of this burden requires larger prospective studies. Accessibility to diagnostic tools like neuroimaging, transcranial Doppler, EEG, and neuropsychological evaluation, as well as to preventive and therapeutic interventions and trained health care providers, should be improved in routine clinical practice.