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Neurologic complications in children hospitalized with influenza infections: Prevalence, risk factors and impact on disease severity

The Pediatric Infectious Disease Journal Apr 15, 2020

Solís-García G, Chacón-Pascual A, González Martínez F, et al. - Pediatric patients hospitalized with influenza were examined for neurologic events and for associated risk factors. Researchers conducted retrospective cohort study including 245 hospitalized patients [Median age: 21 months (interquartile range, 6–57)] with influenza disease over 4 epidemic seasons, focusing on neurologic complications. A previous underlying condition was reported in 47.8%. Eighty six percent were administered oseltamivir; median hospitalization duration was of 4 days (interquartile range, 3–6), and pediatric intensive care unit admission rate was 8.9%. Neurologic event was reported in 29 patients (11.8%), febrile seizures being the most frequent, followed by nonfebrile seizures and encephalopathy. This indicates development of neurologic complications in a significant proportion of influenza-related hospitalized patients. The greatest risk to neurologic events was observed in correlation with previous underlying conditions, which increase disease severity.

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