Schlechtweg K, Chen L, St. Clair CM, et al. - Researchers compared women with neuroendocrine carcinoma of the endometrium (NECE) vs patients with poorly differentiated endometrioid endometrial cancer (EC) in terms of natural history and outcomes by using the National Cancer Database. Overall 28,291 women with EC and 364 women with NECE were examined. The likelihood of receiving adjuvant chemotherapy was more, and the probability of receiving radiation was less in women with NECE. For NECE and for EC, a median survival of 17 months and 144 months, respectively, was documented. For NECE vs EC, the 5-year survival was estimated to be 38.3% vs 68.8%, respectively. For women with NECE vs EC, the hazard ratio for mortality was estimated to be 2.32 in a multivariable model. NECE was identified as a rare and aggressive uterine carcinoma. Presentation with later stage disease and having reduced survival were observed in patients with NECE vs those with poorly differentiated EC.