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Neurodevelopmental outcome of young children with biliary atresia and native liver: Results from the ChiLDReN Study

The Journal of Pediatrics Mar 09, 2018

Ng VL, et al. - The neurodevelopmental outcomes among patients with biliary atresia with their native liver at 12 (group 1) and 24 months (group 2) of age were determined. The variables predictive of neurodevelopmental impairment were identified. An increased risk for neurodevelopmental delays at 12 and 24 months of age was found among individuals with biliary atresia surviving with native livers after hepatoportoenterostomy. Patients with unsuccessful hepatoportoenterostomy exhibited a 4-fold greater likelihood of having neurodevelopmental impairment compared with successful hepatoportoenterostomy. Findings recommended that growth delays and/or complications indicating advanced liver disease ought to alert clinicians to the risk for neurodevelopmental delays, and expedite appropriate interventions.

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