Slomine BS, et al. - In this article, researchers reported the results of detailed neurobehavioural testing in paediatric in-hospital cardiac arrest (IH-CA) survivors, initially comatose after return of circulation, and enrolled in THAPCA-IH, a clinical trial that evaluated two targeted temperature management interventions (hypothermia, 33.0°C or normothermia, 36.8°C; NCT00880087). Among paediatric IH-CA survivors at high risk for unfavorable outcomes, the majority showed a marked reduction in neurobehavioural functioning, across multiple functional domains, with similar functioning at 3 and 12 months. Nearly three-quarters attained Vineland Adaptive Behavior Scales, Second Edition (VABS-II) functional performance composite scores within the broadly normal range.