Philip NS, et al. – For the purpose of this study, transcranial magnetic stimulation (TMS)–associated changes in connectivity in patients with comorbid posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) were evaluated. This study highlighted the central role of the subgenual anterior cingulate cortex (sgACC), default mode network (DMN) and salience network (SN) as predictors of TMS response, and suggest their involvement in mechanisms of action. Notably, there might be network–based biomarkers of clinical response relevant to these commonly comorbid disorders.