Murugan R, et al. - Researchers assessed risk-adjusted 1-year mortality in relation to net ultrafiltration (UF^NET) intensity in critically ill patients with fluid overload receiving renal replacement therapy (RRT) to ultimately gain clarity regarding the optimal intensity of UF^NET in such a patient populace. Using a large academic medical center ICU dataset, they identified patients with fluid overload ≥ 5% of body weight before initiation of RRT. UF_NET intensity was calculated as the net volume of fluid ultrafiltered per day from initiation of either continuous or intermittent RRT until the end of ICU stay, adjusted for patient hospital admission body weight. Intensity of UF_NET was categorized as low (≤ 20 ml/kg/day), moderate (> 20 to ≤ 25 ml/kg/day) or high (> 25 ml/kg/day). In this study, lower 1-year risk-adjusted mortality was observed in relation to UF^NET intensity > 25 ml/kg/day vs ≤ 20 ml/kg/day among these critically ill patients.