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Nephrocalcinosis, renal dysfunction and calculi in patients with primary hypoparathyroidism on long-term conventional therapy

Journal of Clinical Endocrinology and Metabolism Jan 12, 2020

Saha S, et al. - In order to find out nephrocalcinosis, renal dysfunction and calculi, their predictors and progression over long-term follow-up in individuals with primary hypoparathyroidism (PH), researchers conducted an observational study of 165 hypoparathyroid participants at tertiary-care center. By radiographs, USG and CT, hypoparathyroid individuals receiving conventional therapy were investigated. They assessed glomerular-filtration rate (GFR) by Tc-99m-diethylenetriamine penta-acetic acid clearance. They noted nephrocalcinosis in 6.7% of hypoparathyroid patients but not in controls. Nephrocalcinosis was developed in 6.7% of patients with primary hypoparathyroidism and 14% indicated renal dysfunction. There was similar frequency of renal calculi in patients and controls. Nephrocalcinosis was found in 9.0% of patients over 10 years of conventional therapy.
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