Tajaate N, et al. - Neostigmine is widely used to antagonise residual paralysis. The efficacy of neostigmine to antagonise neuromuscular block to attain a train-of-four (TOF) ratio of at least 0.9, was assessed in this systematic review. Researchers recommended, on the basis of analyzed evidence, that the administration of neostigmine be delayed until an advanced degree of prereversal recovery has occurred (i.e. a T1 >25% of baseline), or that a recovery time longer than 15 min be accepted.