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Neonatal and neurodevelopmental outcomes following linezolid for coagulase-negative staphylococcal infection: Real world evidence

The Pediatric Infectious Disease Journal Mar 04, 2020

Sicard M, Moussa A, Barrington K, et al. - Researchers intended to determine if there is an association between linezolid exposure and neurodevelopmental impairment (NDI) or death at 18–21 months of corrected age, in preterm infants with coagulase-negative staphylococci (CoNS) sepsis. Participants in the study were infants ≤ 28 weeks’ gestational age (GA), with CoNS sepsis, admitted between January 2011 and June 2015 in 3 level-3 Canadian NICUs. Of 274 infants involved, 67 were exposed to linezolid. Findings suggested no association of linezolid exposure with the composite outcome of death or significant NDI at 18–21 months. The correlation between linezolid and death may be due to prejudice in indication.
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