Buck CO, Li N, Eaton CB, et al. - Utilizing data from the Health Outcomes and Measures of Environment (HOME) Study, a prospective birth cohort (Cincinnati, Ohio; N = 166), researchers sought to investigate correlations of changes in leptin and adiponectin concentrations from birth to age 12 years with adolescent adiposity and cardiometabolic risk. Using anthropometry, dual-energy x-ray absorptiometry, and fasting serum biomarkers, adiposity and cardiometabolic risk factors were evaluated at age 12 years. Findings suggested no association of most serum adipocytokine concentrations at birth with adiposity or cardiometabolic risk outcomes. Changes in leptin concentrations and adiponectin/leptin ratios were linked to adiposity and cardiometabolic risk scores in this cohort, suggesting that adipocytokine concentrations are potential biomarkers for anticipating excess adiposity and cardiometabolic risk in adolescence.