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Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma

The Lancet Oncology Aug 11, 2017

Alderson D et al. – Four cycles of neoadjuvant epirubicin, cisplatin, and capecitabine (ECX) compared with two cycles of cisplatin and fluorouracil (CF) did not increase survival,

Methods

  • 897 patients with surgically resectable oesophageal adenocarcinoma were recruited; 451 were assigned to the CF group and 446 to the ECX group.
  • The primary outcome measure was overall survival.

Results

  • The median survival was 23.4 months with CF and 26.1 months (22.5–29.7) with ECX (HR = 0.90.

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