Seide D, Diedrich S, Herrle F, et al. - Researchers investigated the effectiveness and safety of negative pressure wound therapy (NPWT) in treatment of subcutaneous abdominal wound healing impairment (SAWHI) after surgery. They conducted a multicenter, multinational, observer-blinded, randomized clinical SAWHI study including 507 adults. The participants underwent negative pressure wound therapy and conventional wound treatment (CWT). In the NPWT arm, wounds closed significantly faster and more often (36.1 days for 92 of 256 study participants) than with conventional wound treatment (39.1 days for 54 of 251 participants). Higher number of participants with wound-related adverse events was reported in the NPWT arm (48 of 234) than in the conventional wound treatment arm (27 of 201). Findings support the effectiveness NPWT is an alternative treatment to conventional wound treatment but with more wound-related adverse events.