Wangaryattawanich P, et al. - In patients with head and neck squamous cell carcinoma with incomplete response interpreted as Neck Imaging Reporting and Data System (NI-RADS) category 2, researchers examined the negative predictive value of the first posttreatment FDG-PET/CT. Between 2008 and 2016, patients with head and neck squamous cell carcinoma treated with chemoradiation or radiation therapy with curative intent in the institution were retrospectively identified. Cervical lymph nodes (59%) was the most common location of tumor recurrence. Data reported that the negative predictive value of the first posttreatment FDG-PET/CT was 85% in patients with an incomplete response after treatment of head and neck squamous cell carcinoma which is lower than the 91% negative predictive value of FDG-PET/CT in patients with an initial complete response. As compared to patients with an initial complete response (NI-RADS 1), patients with an incomplete response (NI-RADS 2) should undergo more frequent clinical and imaging surveillance.