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Nebulized vs IV amikacin as adjunctive antibiotic for hospital and ventilator-acquired pneumonia postcardiac surgeries: A randomized controlled trial

Critical Care Medicine Dec 29, 2017

Hassan NA, et al. - Researchers assessed postcardiothoracic surgical patients with nosocomial pneumonia caused by multidrug-resistant Gram- negative bacilli, in this study, to assess the efficacy and nephrotoxicity of nebulized vs IV amikacin in these subjects. They found that nebulized amikacin vs IV amikacin demonstrated better clinical cure rates, less ICU stay, and fewer days to reach complete recovery and afforded a less nephrotoxic option associated with less deterioration in kidney function.
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