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Near-adult height after growth hormone treatment in children born prematurely—Data from KIGS

Journal of Clinical Endocrinology & Metabolism Jun 09, 2020

Boguszewski MCS, Carlsson M, Lindberg A, et al. - Researchers conducted the study for assessing the influence of prematurity on near-adult height (NAH) after growth hormone (GH) treatment. For children born preterm treated with GH, KIGS (Pfizer International Growth Database) was consulted. The sample consisted of 586 children who were short in stature born preterm with various GH status and with available gestational age (GA), birth weight, and NAH, all treated with GH. No significant height changes in standard deviation scores were observed from the start of puberty to NAH. No link with GA has been found. GH therapy resulted in significant height improvements in preterm born children, especially during prepubertal years and for those with GH deficiency. The degree of prematurity did not impact the response to growth. Treatment with GH had been well tolerated.

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