May A, et al. - Fifty-two thousand seven hundred and ninety-seven men in the National Cancer Database (NCDB) from 2010 to 2015 diagnosed with very low-risk prostate cancer were identified by researchers for analyzing national trends use of androgen deprivation therapy (ADT) outside of standard of care in these patients. The treatment trends and the proportion of men treated with ADT based on race, income, insurance status, treatment facility volume, and Charlson comorbidity were evaluated. Patients were more likely to receive primary ADT when treated at a low-volume facility. The proportion of men who were black and treated with primary ADT increased over time while the proportion of white men decreased. Hence, no change in the trends of the use of primary ADT in men with very low-risk prostate cancer were seen overall. Furthermore, there could be a possibility of over-utilization, particularly among black men and those treated at low-volume facilities.