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NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity

BMC Cancer Sep 13, 2017

Li Q, et al. – In this research, the scientists explored the relationship between N-acetyltransferase 10 (NAT10) and hepatocellular carcinoma (HCC). They illustrated that increased NAT10 expression levels were associated with shortened patient survival and correlated with mutant p53 levels. NAT10 upregulates mutant p53 level and might enhance its tumorigenic activity. Thus, NAT10 could be a potential prognostic and therapeutic candidate for p53-mutated HCC.
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