Chou HD, Chong YJ, Teh WM, et al. - In this retrospective interventional case series, researchers contrasted the outcomes of using a nasal or a temporal inverted internal limiting membrane (ILM) flap assisted by a novel technique in repairing full-thickness macular hole (FTMH). Thirty-nine eyes from 39 patients with FTMH < 600 μm were involved from a single institution. All individuals received vitrectomy with a semicircular single-layered ILM inverted flap assisted by a sub-perfluorocarbon liquid (PFCL) injection of ophthalmic viscoelastic device (OVD) technique. OVD technique sub-PFCL injection secured single-layered flaps intraoperatively and postoperatively. Nasal as well as temporal inverted ILM flaps repaired FTMH and improved visual acuity. However, in the temporal group, both temporal macular thinning and deep inner retinal dimples were significantly greater.