Gallelli G, Cione E, Serra R, et al. - In this pilot study, researchers tested the clinical effectiveness and safety of nano-hydrogel embedded with quercetin and oleic acid in the treatment of lower limb skin wound in patients with diabetes mellitus (DM). They registered and randomized 56 DM patients, mean age 61.7 ± 9.2 years, unsuccessfully treated with mechanical compression to receive an add on treatment with hyaluronic acid (0.2%) or nano-hydrogel embedded with quercetin and oleic acid. According to results, nano-hydrogel treatment embedded with quercetin and oleic acid significantly lessened the wound healing time compared with hyaluronic acid (0.2%) without adverse drug reactions, indicating that this formulation could be used to manage wound healing even if other clinical trials are needed to confirm this finding.