Otsuki S, et al. - Researchers determined the impact of malignant hyperthermia (MH) predisposition on myotoxicity. They analyzed human skeletal muscle samples according to whether their calcium (Ca2⁺)-induced Ca2⁺ release (CICR) rates were accelerated or not. Surplus muscle that remained after the CICR rate test was used. They used the ratiometric dye Fura-2 AM to calculate the 50% effective concentration (EC₅₀) values of three local anesthetics, namely lidocaine, levobupivacaine, and ropivacaine. Also, the unpaired t test was used to assess the significance. Findings demonstrated equivalent myotoxicity of local anesthetics in individuals with and without predisposition to MH.