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Myocardial, renal and intestinal injury in liver resection surgery—A prospective observational pilot study

Acta Anaesthesiologica Scandinavica Apr 22, 2021

Wisén E, Almazrooa A, Bown LS, et al. - Researchers conducted this prospective observational pilot study with the aim to determine the incidence, degree and timing of myocardial, renal and intestinal injury in patients undergoing liver resection surgery utilizing the low central venous pressure (LCVP) technique and the Pringle manoeuvre. They drew blood samples before, during and after elective liver resection until postoperative day (POD) 5 and analyzed high‐sensitive troponin T (hs‐TnT), serum creatinine, urea, intestinal fatty acid binding protein (I‐FABP), D‐lactate, arterial lactate, portal lactate, amylase, as well as urine N‐acetyl‐ß‐D‐glucosaminidase (NAG). The protocol was fulfilled by 18 patients; nearly 30% of these patients had occurrence of myocardial injury post‐operatively and almost 30% had development of transient AKI in the early postoperative period with no tubular injury. In addition, there was a transient increase of the enterocyte damage marker I‐FABP with no signs of gut barrier dysfunction.

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