Stuijfzand WJ, van Rosendael AR, Lin FY, et al. - In this study, the diagnostic accuracy of comprehensive anatomic (obstructive and nonobstructive atherosclerotic plaque) vs functional imaging measures were compared for calculating vessel-specific fractional flow reserve (FFR). Researchers enrolled a sum of 612 patients (64 [10] years; 30% women) with signs and symptoms suggestive of myocardial ischemia from 23 sites. Individuals were included between 2014 and 2017. The data revealed that in the diagnosis of invasive FFR, a comprehensive anatomic interpretation with CCTA, including quantification of obstructive and nonobstructive atherosclerotic plaque, was superior to functional imaging. The results of this study indicated that comprehensive CCTA measures improve prediction of vessel-specific coronary physiology more so than stress-induced alterations in myocardial perfusion.