Bradbury CA, Pell J, Hill Q, et al. - For first-line treatment of immune thrombocytopenia, administration of mycophenolate mofetil along with a glucocorticoid, vs glucocorticoid only, linked with a greater response and a lower risk of refractory or relapsed immune thrombocytopenia.

• A multicenter, open-label, randomized, controlled trial.

• A total of 120 patients with immune thrombocytopenia were assigned to receive first-line treatment with a glucocorticoid only or combined glucocorticoid and mycophenolate mofetil.

• Fewer treatment failures (22% [13 of 59 patients] vs 44% [27 of 61 patients]) and greater response (91.5% of patients having platelet counts greater than 100×10⁹ per liter vs 63.9%) were recorded in the mycophenolate mofetil group vs the glucocorticoid-only group.

• However, patients described somewhat reduced quality of life regarding physical function and fatigue in correlation with receiving combination treatment.