Lintel NJ, et al. - During this analysis, an inquiry was carried out of the efficacy of major vault protein (MVP) immunohistochemistry (IHC) with the intention of distinguishing leiomyosarcoma from leiomyoma (LM) and bizarre leiomyoma (BLM). Findings disclosed that MVP (clone 1014, Santa Cruz Biotechnology, Dallas TX) appeared to be 50% sensitive and 100% specific when comparing LMS to LM, by IHC. COMT (clone FL-271, Santa Cruz Biotechnology, Dallas TX) displayed a sensitivity of 38% and a specificity of 88%. The yielded data reported that 6/7 BLM presented with the expression of MVP similar to LM. Hence, immunohistochemical staining for MVP served as a beneficial adjunct in distinguishing LMS from LM and BLM in difficult cases.