Li G, Tian DD, Wang X, et al. - Given a possible correlation of suboptimal tissue perfusion and oxygenation during surgery with postoperative nausea and vomiting in some patients, researchers conducted a trial testing the hypothesis that postoperative nausea and vomiting could be reduced with muscular tissue oxygen saturation–guided intraoperative care. In this multicenter, pragmatic, patient- and assessor-blinded randomized controlled (1:1 ratio) trial, randomization was performed of nonsmoking women (n = 800), 18 to 65 yr old, and having elective laparoscopic surgery involving hysterectomy, to receive either intraoperative muscular tissue oxygen saturation–guided care or usual care. Findings support the effectiveness of personalized, goal-directed, muscular tissue oxygen saturation–guided intraoperative care in treating decreased muscular tissue oxygen saturation however, it does not led to reduction in the incidence of 24-h posthysterectomy nausea and vomiting.