Giovannucci EL, et al. - Researchers performed a narrative literature review and summarized the existing evidence from large prospective cohort studies on muscle strengthening activities and risk of major chronic diseases and mortality in adults generally free of major non-communicable diseases (NCDs) at baseline. The study demonstrates that engagement in muscle-strengthening activities over 1–2 sessions (or approximately 60–150 min) per week was correlated with decreased risk of cardiovascular disease (7 studies; approximately 20–25% reduction), type 2 diabetes (4 studies; approximately 30% reduction), cancer mortality (4 studies; approximately 15–20% reduction) as well as all-cause mortality (6 studies; approximately 20–25% reduction). Caution is suggested for training exceeding 2.5 hours per week, although data are limited. There is a need for future trials to better understand the influence of frequency, duration, and intensity of muscle-strengthening activities on major NCDs and mortality in diverse populations.