Feldstein LR, Rose EB, Horwitz SM, et al. - Researchers sought to understand the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal correlation with coronavirus disease 2019 (Covid-19), given the clinical and public health implications of the syndrome. From March 15 to May 20, 2020, targeted surveillance for MIS-C was conducted in pediatric health centers across the United States. They assessed 186 patients (median age: 8.3 years) with MIS-C in 26 states. Among these cases, 115 (62%) were male, 135 (73%) had previously been healthy, 131 (70%) were positive for SARS-CoV-2 by RT-PCR or antibody testing, and 164 (88%) were hospitalized after April 16, 2020. Following organ-system involvement was reported: the gastrointestinal system in 171 patients (92%), cardiovascular in 149 (80%), hematologic in 142 (76%), mucocutaneous in 137 (74%), and respiratory in 131 (70%). The median duration of hospitalization was 7 days (interquartile range, 4 to 10); intensive care was required in 148 patients (80%), mechanical ventilation was provided to 37 (20%) cases, vasoactive support was required in 90 (48%), and death was reported for 4 (2%) cases. Observations suggest that previously healthy children and adolescents had serious and life-threatening illness due to multisystem inflammatory syndrome linked with SARS-CoV-2.