Zhu Z, Zhong C, Guo D, et al. - In this prospective multicenter study, researchers assessed whether the risk prediction of post-stroke cognitive impairment can be enhanced using multiple new biomarkers representing several pathophysiological pathways. Participants included 638 patients with ischemic stroke and high blood pressure based on a random subsample from China Antihypertensive Trial in Acute Ischemic Stroke. Among the participants, 12 circulating biomarkers were measured. At 3 months post-stroke, they evaluated cognitive impairment with definitions of Mini-Mental State Examination score < 27 or Montreal Cognitive Assessment score < 25. They found that an improved risk prediction of cognitive impairment among ischemic stroke patients with elevated blood pressure can be achieved by combining rheumatoid factor, matrix metalloproteinase-9, and total homocysteine.