Mendes A, et al. - Researchers investigated if there was a correlation between multimorbidity and Alzheimer’s disease (AD) neuroimaging markers in cognitively normal older adults. Data were gathered for 318 adults aged 70–85 years recruited from the community to an ongoing prospective monocentric cohort regarding 14 comorbidities. Findings revealed that obesity and excessive alcohol use were linked with lower fluorodeoxyglucose positron emission tomography (FDG-PET) values. On the other hand, obstructive sleep apnea and mood disorders were associated with lower amyloid positron emission tomography (amyloid-PET) standardized uptake values (SUV) ratios. It was observed that multimorbidity was correlated with preclinical AD imaging markers of neurodegeneration. However, no association with amyloid was found.