Kyrgidis A, et al. - In this prospective, monocentric, single-group open study involving 49 patients (mean age was 18.2 ± 3.7 years), researchers assessed the application of multimodal clinical imaging (MCI), a combination of imaging technology and computation, in the evaluation of acne lesions in a clinical study setting. They assessed the effectiveness and tolerance of a cosmetic product in individuals with mild-to-moderate facial acne by classical clinical counting (CCC) – change in the total/inflammatory/noninflammatory acne lesion number vs baseline (D0) – Investigator Global Assessment and self-reported outcomes. Data reported that the mean acne duration was 3.8 ± 2.8 years. Findings revealed that MCI, first applied in a small clinical study setting, is at least as reliable as CCC and can enable a sensitive longitudinal evaluation of single acne lesions and their response to products, particularly in conditions where clinical evaluation reaches its limitations.