Han YY, Zhang X, Wang J, et al. - Researchers undertook this cross-sectional analysis to investigate the link between phenotype overlap and clinical as well as inflammatory profiles of asthma. Multidimensional evaluations were performed among adult patients with stable asthma (n = 522). Experts defined the 10 most frequent phenotypes of asthma and then divided them into those often related to Type (T) 2 or non-T2 inflammation. Phenotype overlap was identified in 73.4% (n = 383) of 522 participants. A positive correlation of T2 phenotype overlap scores with eosinophils, IgE, and fractional exhaled nitric oxide, as well as negative correlation with Asthma Quality of Life Questionnaire, sputum neutrophils, IL-17A, IL-8, and TNF-α, was found. Overall, the presence of phenotype overlap was an extremely common finding in this study population with asthma, and a significant link of phenotype overlap with clinical as well as inflammatory profiles was evident in this study. Unresponsiveness to medications might be seen in patients with phenotypes related to mixed T2 and non-T2 inflammation, this could be because of increased non-T2 inflammation. The identification of clinically relevant phenotype overlap was enabled by multidimensional asthma assessment.