Visser AE, et al. - Using a validated and harmonized questionnaire, researchers gauged the link between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case–control studies in three European countries. The enrollment consisted of subjects with incident ALS and controls from five population-based registers in The Netherlands, Ireland and Italy. A linear correlation seen between ALS and PA in leisure time and occupational activities and all activities combined, displaying certain heterogeneity between regions. The most evident link was discovered in the Irish and Italian cohorts. This study provided more evidence that PA and risk of ALS had a positive connection.