Barker T, Henriksen VT, Rogers VE, et al. - Researchers undertook this randomized, double-blind, placebo controlled study to determine whether a multi-vitamin with mineral supplement consumed prior to modifies the circulating interleukin (IL)-6/IL-10 ratio after total knee arthroplasty (TKA). This analysis involved 21 patients receiving elective, primary, unilateral TKA, who were randomized to a placebo (PL, n = 11) or multi-vitamin with mineral supplement (MV, n = 10). Experts administered supplements daily starting about 6-weeks before surgery. As a result of MV supplementation, there was a rise in serum 25-hydroxyvitamin D as well as a significant rise in plasma ascorbic acid and plasma α-tocopherol prior to surgery without mitigation of the postoperative IL-6 and high-sensitivity CRP rises. The MV group exhibited significantly blunted postoperative rise in the serum IL-6/IL-10 ratio following surgery. Overall, it was inferred that the pro-inflammatory predominance post-TKA might be reduced by taking a multi-vitamin with mineral supplement daily for several weeks prior to surgery.