Schug S, Pogatzki-Zahn E, Phillips LD, et al. - As identification of optimal treatment is challenging in an acute postoperative setting, researchers here performed quantification and comparison of the efficacy and safety data of various drugs using multi-criteria decision analysis (MCDA). The MCDA model included 17 criteria: three for efficacy and 14 for safety. Efficacy and safety had relative weightings of 64% and 36%, respectively in the primary model. In efficacy and safety criteria, the highest values were given to pain relief (relative weight, 29%) and gastrointestinal effects (12%). The highest overall score was observed for parecoxib (93), followed by diclofenac (80), and ketorolac (75). The lowest score was recorded for morphine (57), due to the lack of an opioid sparing effect. This MCDA-based assessment indicates the most favorable efficacy-safety profile of parecoxib among the assessed postoperative analgesics.